In situ carcinoma of the conjunctiva: surgical excision associated with cryotherapy

BACKGROUND Although frequently underdiagnosed, squamous cell carcinoma is the most commonly observed malignancy of the conjunctiva. Multiple different treatments have been proposed to date. The purpose of this paper is to report our experience in the treatment of In situ carcinoma of the conjunctiva by surgical excision associated with cryotherapy. METHODS Four eyes in four consecutive patients (two men and two women) of average age 53.2 (range 39-71) years at the time of diagnosis of ocular surface squamous neoplasia were treated by simple surgical excision and cryotherapy of the resulting surgical bed margins. In all cases, the diagnosis of in situ carcinoma was confirmed histopathologically. RESULTS On histopathology, the edges of the surgical specimens were free of malignant cells in three of four patients. All patients showed excellent evolution without recurrence. Mean follow-up was 6.5 (range 2-14) years. CONCLUSION In situ carcinoma of the conjunctiva may be simply and successfully treated with surgical excision and cryotherapy.